http://hdl.handle.net/11422/25225 2026-04-19T18:00:39Z 2026-04-19T18:00:39Z Canoilas, Débora Pimentel http://hdl.handle.net/11422/27789 2025-12-03T03:00:13Z 2024-01-01T00:00:00Z

Title: Revisão narrativa sobre colangite esclerosante primária Author(s)/Inventor(s): Canoilas, Débora Pimentel Advisor: Rotman, Vivan Abstract: Primary sclerosing cholangitis is a chronic, cholestatic liver disease that can involve the entire biliary tree caused by diffuse inflammation, fibrosis and stenosis. The pathogenesis is unkown, but it is established as being imune mediated. It is a progressive disorder which can ultimately lead to biliary cirrhosis, portal hypertension and hepatic failure. Most patients are asymptomatic at presentation.The diagnosis is established by cholangiography and serum biochemical tests indicate cholestasis. Liver biopsy is not routinely indicated. There is a higher risck of malignacy, above all, cholangiocarcinoma, gallbladder and colorectal cancer. Primary sclerosing cholangitis has no curative treatment,except liver transplant. Medical treatment with ursodeoxycholic acid may improve laboratory findings. There is no medical treatment capable of slow progression of the disease and outcome. This is a narative review about the main topics related to primary sclerosing cholangitis, which includes, epidemiology, pathogenesis, clinical features, diagnosis, prognosis malignacy screening and treatment. Publisher: Universidade Federal do Rio de Janeiro Type: Trabalho de conclusão de especialização

2024-01-01T00:00:00Z Castro, Nathalia Carraro Eduardo de http://hdl.handle.net/11422/27788 2025-12-03T03:00:14Z 2024-01-01T00:00:00Z

Title: Revisão bibliográfica sobre colangite biliar primária Author(s)/Inventor(s): Castro, Nathalia Carraro Eduardo de Advisor: Rotman, Vivian Abstract: This is a narrative review of the main topics related to primary biliary cholangitis. It reviews aspects of epidemiology, hepatic and extrahepatic clinical manifestations, laboratory findings, diagnostic criteria, prognostic evaluation and therapeutic management. Primary biliary cholangitis is an autoimmune disease that is more prevalent in middle-aged women and manifests with chronic and progressive intrahepatic cholestasis, and may have asymptomatic laboratory alterations or decompensated liver cirrhosis. It is diagnosed by the combination of a tripod: cholestasis, autoimmunity represented by autoantibodies and compatible liver biopsy. The first-line drug for therapy is ursodeoxycholic acid. New second-line drugs are currently being studied. This work prioritizes a review of the evidence that supports the new drugs and that positively expands the possibility of offering adequate control of this disease. In addition, the study highlights some serological details that help in the diagnosis of atypical forms of the disease. Publisher: Universidade Federal do Rio de Janeiro Type: Trabalho de conclusão de especialização

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