http://hdl.handle.net/11422/116 Mon, 13 Jul 2026 01:08:22 GMT 2026-07-13T01:08:22Z http://hdl.handle.net/11422/29270 Title: A paleomastofauna das bacias eoterciárias brasileiras e sua importância na datação das bacias de Itaboraí e Taubaté Author(s)/Inventor(s): Bergqvist, Lílian Paglarelli; Ribeiro, Ana Maria Abstract: The current knowledge of the fossil mammals of two Paleogene basins of Brazil, Itaboraí Basin (State of Rio de Janeiro) and Taubaté Basin (State of São Paulo) is summarized We also address the age of these deposits based on the fossil mammals. The 34 species known from the Itaboraí basin were collected in fissure-fill deposits. Though ungulate remains are the most abundant, marsupials are the most diverse group. Litopterna is the better known order, though notoungulates are the most frequent. the fauna of the Tremembá Formation (Taubaté Basin) is significantly less varied than that of Itaboraí, and is represented by only 10 species, of which 40% belong to the order Notoungulata. Recent studies by the authors on the mammal fauna of Itaboraí and Tremembé suggest that the sedimentary sequence of the Itaboraí Basin was deposited partially during the early Paleocene and part during the late Paleocene. The fissure-fill deposits are of Itaboraian land-mammal age, but certainly continued through the Riochican. The generalized condition of the cingulates and notoungulates of the Tremembé Formation, together with palaeopalynologic and palaeoclimatic data, suggest that the mammal fauna may belong to the beginning of the Deseadan age.; Este estudio tiene como objetivo presentar una síntesis del conocimiento actual acerca de los mamíferos de las cuencas paleógenas de Itaboraí, estado de Río de Janeiro, y Taubaté, estado de São Paulo, Brasil, y además hacer nuevas inferencias acerca de la edad de estas sedimentitas baseados en la paleomastofauna. En la cuenca de Itaboraí son conocidas 34 especies de mamíferos, oriundas de canales de disolución que atravesaban el calcáreo que rellenaba la cuenca. Los ungulados son los fósiles más comunes, pero los marsupiales son los que presentan mayor diversidad (21 especies). Los ungulados son los fósiles más comunes, pero los marsupiales son los que presentan mayor diversidad (21 especies). Los litopternas son el grupo mejor conocido, y los notoungulados los más abundantes de todos. La fauna de la Formación Tremembé (cuenca de Taubaté) es poco variada en comparación con aquélla de la cuenca de Itaboraí, existiendo solamente diez especies, 40% de estas pertenecen al orden Notoungulata. Estudios recientes desarrollados sobre la fauna de mamíferos de las cuencas de Itaboraí e Taubaté posibilitaron nuevas evaluaciones para la datación de las unidades mencionadas. En la cuenca de Itaboraí, la secuencia fosilífera fue situada. Publisher: Asociación Paleontológica Argentina Type: Artigo Wed, 30 Dec 1998 00:00:00 GMT http://hdl.handle.net/11422/29270 1998-12-30T00:00:00Z http://hdl.handle.net/11422/27698 Title: The influence of brown algae alginates on phenolic compounds capability of ultraviolet radiation absorption in vitro Author(s)/Inventor(s): Salgado, Leonardo Tavares; Tomazetto, Rodrigo; Cinelli, Leonardo Paes; Farina, Marcos; Amado Filho, Gilberto Menezes Abstract: Brown algae phenolic compounds (PC) are secondary metabolites that participate in many biological processes, such as ultraviolet radiation (UV) protection, polyspermy blocking and trace metals bounding. Recently, PC has also been studied due to possible interactions with cell wall polysaccharides. However, there are few evidences of these interactions and their influence in physiological processes. The interactions between PC from the brown alga Padina gymnospora and alginates and the influence of these interactions on the UV absorption properties of PC were investigated in this work. Chromatography and spectrophotometry techniques were used to isolate, characterize and determine UV absorption capacity of studied compounds. Even after the P. gymnospora polysaccharide extraction and isolating methods, the PC was maintained linked to the alginate. The interaction of alginates with PC did not cause modifications on absorbance pattern of electromagnetic spectrum (UV-VIS-IR). The UV absorbance capability of PC linked to alginate was maintained for a longer period of time if compared with the purified PC. The obtained results reveal the strong linkage between PC and alginates and that these linkages preserve the UV absorption capability of PC along time. Publisher: Universidade de São Paulo Type: Artigo Fri, 01 Jun 2007 00:00:00 GMT http://hdl.handle.net/11422/27698 2007-06-01T00:00:00Z http://hdl.handle.net/11422/27633 Title: Application of 4D-QSAR studies to a series of raloxifene analogs and design of potential selective estrogen receptor modulators Author(s)/Inventor(s): Sodero, Ana Carolina Rennó; Romeiro, Nelilma Correia; Cunha, Elaine Fontes Ferreira da; Magalhães, Uiaran de Oliveira; Alencastro, Ricardo Bicca de; Rodrigues, Carlos Rangel; Cabral, Lúcio Mendes; Castro, Helena Carla; Albuquerque, Magaly Girão Abstract: Four-dimensional quantitative structure-activity relationship (4D-QSAR) analysis was applied on a series of 54 2-arylbenzothiophene derivatives, synthesized by Grese and coworkers, based on raloxifene (an estrogen receptor-alpha antagonist), and evaluated as ERα ligands and as inhibitors of estrogen-stimulated proliferation of MCF-7 breast cancer cells. The conformations of each analogue, sampled from a molecular dynamics simulation, were placed in a grid cell lattice according to three trial alignments, considering two grid cell sizes (1.0 and 2.0 Å). The QSAR equations, generated by a combined scheme of genetic algorithms (GA) and partial least squares (PLS) regression, were evaluated by “leave-one-out” cross-validation, using a training set of 41 compounds. External validation was performed using a test set of 13 compounds. The obtained 4D-QSAR models are in agreement with the proposed mechanism of action for raloxifene. This study allowed a quantitative prediction of compounds’ potency and supported the design of new raloxifene analogs. Publisher: Multidisciplinary Digital Publishing Institute Type: Artigo Tue, 05 Jun 2012 00:00:00 GMT http://hdl.handle.net/11422/27633 2012-06-05T00:00:00Z http://hdl.handle.net/11422/27632 Title: Molecular docking and molecular dynamic studies of semi-synthetic piperidine alkaloids as acetylcholinesterase inhibitors Author(s)/Inventor(s): Danuello, Amanda; Romeiro, Nelilma Correia; Giesel, Guilherme Menegon; Pivatto, Marcos; Viegas Junior, Cláudio; Verli, Hugo; Barreiro, Eliezer Jesus de Lacerda; Fraga, Carlos Alberto Manssour; Castro, Newton Gonçalves de; Bolzani, Vanderlan da Silva Abstract: The mixture of semi-synthetic derivatives ( )-3-O-acetyl-cassine hydrochloride and ( )-3-O-acetyl-spectaline hydrochloride, prepared from the mixture of natural alkaloids ( )-cassine and ( )-spectaline (4:1) isolated from Senna spectabilis, has been shown to be a potent acetylcholinesterase (AChE) inhibitor, thereby prompting further molecular studies. In this sense, docking and dynamic molecular studies were carried out in this work, aiming to acquire a deeper understanding about all the structural aspects of molecules ( )-3-O-acetyl-cassine and ( )-3-O-acetyl-spectaline hydrochlorides, which differ with respect to their AChE inhibitory potentials. Both molecules establish important interactions with the peripheral anionic site within the catalytic gorge of Torpedo californica AChE. However, only the major compound ( )-3-O-acetyl-cassine hydrochloride significantly interacts with the catalytic triad. Explicit-solvent molecular dynamic simulations were conducted in order to gain better understanding about the hypothetical interactions taking place between the semi-synthetic alkaloid molecules ( )-3-O-acetyl-cassine and ( )-3-O-acetyl-spectaline hydrochlorides and AChE. The data obtained in this study indicated that ( )-3-O-acetyl-cassine hydrochloride is the most potent inhibitor of AChE possibly due to the favorable interactions of this molecule with the target protein, with lower desolvation cost. These results suggested that the size of the side chain has an effect on the inhibitory potential of the evaluated molecules and may represent the starting point for the development of new derivatives of ( )-3-O-acetyl-cassine hydrochloride, with a view to the discovery of new effective AChE inhibitors. Publisher: Sociedade Brasileira de Química Type: Artigo Sun, 01 Jan 2012 00:00:00 GMT http://hdl.handle.net/11422/27632 2012-01-01T00:00:00Z