http://hdl.handle.net/11422/25216 Thu, 30 Jul 2026 15:40:19 GMT 2026-07-30T15:40:19Z http://hdl.handle.net/11422/29788 Title: Hipertermia maligna: uma revisão da literatura em Anestesiologia Author(s)/Inventor(s): Neves, Marcos Vinícius Paulino; Menezes, Paulo César Júnior Advisor: Vieira, Márcio Carneiro Abstract: Malignant hyperthermia (MH) is a rare and potentially fatal autosomal dominant pharmacogenetic myopathy triggered by halogenated inhaled anesthetic agents and succinylcholine. The objective of this study is to review the scientific literature on malignant hyperthermia in the context of anesthesiology. To understand the nature of this rare, potentially fatal pharmacogenetic syndrome, identify risk factors, such as anesthetic agents, and its pathophysiology, related to impaired calcium homeostasis. The review seeks to identify the list of triggering agents and the population at risk; analyze clinical manifestations and diagnostic criteria; establish treatment and perioperative management strategies; and discuss national and international prevention protocols. Search sources include PubMed, SciELO, ScienceDirect, LILACS, and Google Scholar, covering publications from the last 15 years. The keywords used were: “malignant hyperthermia”, “dantrolene”, “anesthesia complications” and “hypermetabolic crisis”. Original articles, theses, reviews, and guidelines were included, and isolated case reports or articles not directly relevant to MH were excluded. Malignant hyperthermia is a potentially fatal genetic disease related to excessive muscle metabolism that occurs after exposure to inhalational anesthetics. The literature indicates that, despite its low incidence, MH remains a feared complication in anesthesia due to its fulminant progression. The availability of dantrolene and team training are critical factors in reducing mortality. Early recognition, combined with prompt administration of dantrolene, is crucial for survival. National and international protocols should be widely disseminated and implemented to ensure the safety of anesthetized patients. Publisher: Universidade Federal do Rio de Janeiro Type: Trabalho de conclusão de especialização Tue, 25 Nov 2025 00:00:00 GMT http://hdl.handle.net/11422/29788 2025-11-25T00:00:00Z http://hdl.handle.net/11422/29784 Title: Alteração dos índices hematimétricos após amputação de membro inferior a nível supra e infra patelar em um hospital universitário: análise observacional retrospectiva Author(s)/Inventor(s): Cerqueira, Newton Furtado Advisor: Ugenti, Viviana Abstract: Peripheral arterial occlusive disease (PAOD) is the term used to define chronic atherosclerotic obstruction of the arteries. PAOD may have a prevalence in the population ranging from 3.4% to 5.4%, according to data obtained in Europe. It is a condition that can lead to significant physical limitation and, in severe cases, to lower-limb amputation. Evidence shows that patients with PAOD and anemia have a higher risk of amputation, and that perioperative transfusion may add risks to the patient. In this context, this observational, retrospective, single-center study analyzed 41 patients who underwent lower-limb amputation at the supra- or infrapatellar level. Hemoglobin and hematocrit levels were measured before the procedure and up to a maximum of 72 hours after surgery, along with information related to the type of anesthesia, chronic medication use, and type of surgery. A median preoperative hemoglobin level of 9 g/dL (IQR 2.5) was observed, whereas the median postoperative hemoglobin level was 8 g/dL (IQR 2). The median preoperative hematocrit was 27.3% (IQR 6), while the median postoperative hematocrit was 24% (IQR 3.7). The use of aspirin did not increase the likelihood of hemoglobin drop after supra- or infrapatellar amputation (p = 0.863). Multiple logistic regression showed that the type of amputation (suprapatellar vs. infrapatellar) was not associated with the occurrence of a significant drop in hemoglobin (p = 0.578 and p = 0.970, respectively). These findings may help support decision-making regarding perioperative transfusion in these patients. Publisher: Universidade Federal do Rio de Janeiro Type: Trabalho de conclusão de especialização Sun, 30 Nov 2025 00:00:00 GMT http://hdl.handle.net/11422/29784 2025-11-30T00:00:00Z http://hdl.handle.net/11422/27251 Title: Uso de ultrassonografia para avaliação de via aérea difícil em hospital universitário no Rio de Janeiro: um estudo observacional prospectivo Author(s)/Inventor(s): Mesquita, Laís Rangel; Moraes, Luciana Chan Azevedo de Advisor: Ferreira, Nathalia Gouveia de Araújo Abstract: Not available. Publisher: Universidade Federal do Rio de Janeiro Type: Trabalho de conclusão de especialização Mon, 01 Jan 2024 00:00:00 GMT http://hdl.handle.net/11422/27251 2024-01-01T00:00:00Z