Fatores associados à remissão da neoplasia tromfoblástica gestacional em pacientes após tratamento com quimioterapia por agente único

Abstract

Introduction: Gestational trophoblastic disease (GTD) comprises a group of rare pregnancy disorders arising from placental trophoblast. It ranges from benign forms such as complete and partial hydatidiform mole (HM) to malignant spectra called gestational trophoblastic neoplasia (GTN). It is highly responsive to chemotherapy with a cure rate that generally exceeds 90%, making it possible to preserve reproductive function. Objetive: Study the factors associated with the remission of GTN after first- and second-linetreatment with single-agent chemotherapy. METHODS Retrospective, collaborative cohort study of patients diagnosed with GTN followed at the GTD referral center at Maternity School of the Federal University of Rio de Janeiro (UFRJ) and at the New England Trophoblastic Disease Center (NETDC) at the Brigham and Women's Hospital and Dana-Farber Cancer Institute, between 1964 and 2018. Background: Treatment of GTN is globally preceded by the classification according to the WHO/FIGO prognostic risk score, which characterizes the disease at low-risk or high-risk. Many low-risk GTN patients with higher scores (five and six)presentelevated rates of single-agent chemoresistance, discouraging many referral centers for GTDworldwide from choosing this line of treatment. Studying the profile of these patients with good response is of fundamental importance to avoid unnecessary exposure to multiple drugs and their side effects.