Doença da crioaglutinina: revisão de literatura

Abstract

Cold agglutinin disease is a rare entity, but has been better described and defined in recent years. It is a disease with a clonal substrate leading to the formation of autoantibodies capable of agglutinating red blood cells at low temperatures. Despite new advances, especially in the treatment of CAD, there is still much information based on observational studies, requiring further investigation. In recent years, with the understanding of the clonal pattern of the disease, targeted therapies against B cells and also inhibition of the complement system have been studied with promising results. Further studies are needed to find the best treatment for CAD.