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http://hdl.handle.net/11422/27629
| Type: | Artigo |
| Title: | Proteínas tirosinas quinases: desafios do desenvolvimento de fármacos para a terapia do câncer |
| Author(s)/Inventor(s): | Avila, Carolina Martins Romeiro, Nelilma Correia |
| Abstract: | Este trabalho descreve informações recentes sobre as proteínas tirosinas quinases e sua importância como alvos moleculares na terapia do câncer. Atenção especial é dada aos estudos de difração de raios-X de complexos inibidores-enzimas que elucidaram novos modos de ligação da segunda geração de fármacos anticâncer, inibidores de tirosinas quinases. |
| Abstract: | This paper describes recent information on protein tyrosine kinases and their importance as molecular targets in cancer therapy, as well as the challenges involved in selective binding of drugs while overcoming resistance. Special attention is given to X-ray diffraction studies of enzyme-inhibitor co-crystals, which have demonstrated new binding modes of the second generation of anticancer drugs, tyrosine kinase inhibitors. |
| Keywords: | Receptores proteína tirosina quinases Antineoplásicos Receptor protein-tyrosine kinases Antineoplastic agents |
| Subject CNPq: | CNPQ::CIENCIAS DA SAUDE::FARMACIA CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA |
| Production unit: | Faculdade de Farmácia Instituto de Biodiversidade e Sustentabilidade |
| Publisher: | Sociedade Brasileira de Química |
| In: | Revista Virtual de Química |
| Volume: | 2 |
| Issue: | 1 |
| Issue Date: | 30-Aug-2010 |
| DOI: | 10.5935/1984-6835.20100007 |
| Publisher country: | Brasil |
| Language: | por |
| Right access: | Acesso Aberto |
| ISSN: | 1984-6835 |
| Citation: | AVILA, Carolina Martins; ROMEIRO, Nelilma Correia. Proteínas tirosinas quinases: desafios do desenvolvimento de fármacos para a terapia do câncer. Revista Virtual de Química, v. 2, n. 1, jan./mar. 2010, p. 59-82. |
| Appears in Collections: | Ciências da Saúde |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| CMAvila.pdf | 989.43 kB | Adobe PDF | View/Open |
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