Mitos e verdades das interações alimentares da tranilcipromina com a tiramina

Abstract

The interaction between tranylcypromine and tyramine is often surrounded by myths and misinformation, leading to excessive dietary restrictions in patients using monoamine oxidase inhibitors (MAOIs). This review examines the scientific evidence regarding this interaction and highlights the importance of tranylcypromine as an effective treatment for ntreatment-resistant depression. The findings demonstrate that hypertensive reactions caused by tyramine ingestion are mostly mild and self-limited, not requiring immediate pharmacological intervention. Furthermore, the review shows that the dietary restrictions recommended for patients on MAOIs are, in most cases, unnecessary, as many foods, when properly prepared, do not pose a significant risk. The analysis also reveals that the concurrent use of selective norepinephrine reuptake inhibitors (SNRIs) and nortriptyline can attenuate tyramine's effects on blood pressure. Misinformation about the interaction between tranylcypromine and tyramine contributes to the underuse of this effective medication. Therefore, a more balanced and individualized approach to dietary management in patients on tranylcypromine treatment is crucial, as well as updating clinical guidelines based on the latest evidence. Promoting effective communication between doctors and patients is also emphasized as a key factor in ensuring treatment adherence and improving patients' quality of life. The work concludes with a recommendation for further clinical studies to better explore the relationship between tranylcypromine and tyramine in different contexts and populations.