Desenvolvimento membranas de poli(ácido lático) para aplicação com conduíte de guia neural

Abstract

Recorte de tela efetuado: 18/10/2019 13:36

Recorte de tela efetuado: 18/10/2019 13:35

Membrane technology has been studied for preparing artificial transplants for peripheral nerve injury, also known as Neural Guide Conduits (NGC). The purpose of this work was to develop acid) (PDLLA) hollow fibers as NGC, and evaluate their performance on in vivo functional recovery. The development of the hollow fibers brought a wider understanding on kinetics and thermodynamic aspects during PLA membrane synthesis, allowing better control of its transport properties and morphology. The study of preparing conditions and investigation of different solvents and additives allowed the production of hollow fibers with both fingerlike and spongelike morphologies, with rejections of 100% of BSA (67 kDa) and 83 to 100% of lysozyme (17 kl)a), with water permeabilities from O to 9.38 /m2 h bar. In vivo functional evaluation was able to elucidate questions about the influence of porosity of NGC during the treatment. Results showed that the functional recovery of the synthesized membranes in this work were equal or superior compared to values reported in the open literature, mostly regarded to sensorial evaluation. Nonporous hollow fibers showed faster sensorial recovery (2 weeks) while full recovery after 5 weeks was observed with porous membranes.