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http://hdl.handle.net/11422/27333
| Type: | Artigo |
| Title: | DAPK and P16 methylation and HPV and EBV infection in small cell carcinoma of cervix: a case report |
| Author(s)/Inventor(s): | Furtado, Yara Lúcia Ribeiro, Fernanda Lattario Silveira, Filomena Aste Carvalho, Maria da Glória da Costa Almeida Filho, Gutemberg Leão de |
| Abstract: | Indisponível. |
| Abstract: | Purpose: Small cell carcinoma (SMCC) of the cervix is rare and aggressive tumor, often diagnosed in an advanced stage and their prognosis is generally poor. A case of SMCC showing Human Papillomavirus (HPV) and Epstein barr virus (EBV) infection and Death-associated protein kinase (DAPK) and p16 genes methylation is presented. A 74-year-old woman was diagnosed as having stage IB2 of SMCC. Methods: HPV and EBV infection and DAPK and p16 gene methylation were found using molecular approaches. Results: The sample was positive for HPV and EBV infection and showed DAPK and p16 promoter regions methylated Conclusion: Methylation of DAPK and p16 gene could be used as a molecular marker in cervical cancer. |
| Keywords: | Proteínas quinases associadas com morte celular Papilomavírus humanos Neoplasias do colo do útero Death-associated protein kinases Human Papillomavirus Viruses Uterine cervical neoplasms HPV |
| Subject CNPq: | CNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA::GINECOLOGIA E OBSTETRICIA |
| Production unit: | Instituto de Ginecologia |
| Publisher: | Hilaris SRL |
| In: | Journal of Clinical Case Reports |
| Volume: | 6 |
| Issue: | 4 |
| Issue Date: | 2016 |
| DOI: | 10.4172/2165-7920.1000781 |
| Publisher country: | Bélgica |
| Language: | eng |
| Right access: | Acesso Aberto |
| ISSN: | 2165-7920 |
| Appears in Collections: | Ciências da Saúde |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| GLAlmeida_DAPK.pdf | 169.9 kB | Adobe PDF | View/Open |
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