Por favor, use este identificador para citar o enlazar este ítem: http://hdl.handle.net/11422/27333

Especie: Artigo
Título : DAPK and P16 methylation and HPV and EBV infection in small cell carcinoma of cervix: a case report
Autor(es)/Inventor(es): Furtado, Yara Lúcia
Ribeiro, Fernanda Lattario
Silveira, Filomena Aste
Carvalho, Maria da Glória da Costa
Almeida Filho, Gutemberg Leão de
Resumen: Indisponível.
Resumen: Purpose: Small cell carcinoma (SMCC) of the cervix is rare and aggressive tumor, often diagnosed in an advanced stage and their prognosis is generally poor. A case of SMCC showing Human Papillomavirus (HPV) and Epstein barr virus (EBV) infection and Death-associated protein kinase (DAPK) and p16 genes methylation is presented. A 74-year-old woman was diagnosed as having stage IB2 of SMCC. Methods: HPV and EBV infection and DAPK and p16 gene methylation were found using molecular approaches. Results: The sample was positive for HPV and EBV infection and showed DAPK and p16 promoter regions methylated Conclusion: Methylation of DAPK and p16 gene could be used as a molecular marker in cervical cancer.
Materia: Proteínas quinases associadas com morte celular
Papilomavírus humanos
Neoplasias do colo do útero
Death-associated protein kinases
Human Papillomavirus Viruses
Uterine cervical neoplasms
HPV
Materia CNPq: CNPQ::CIENCIAS DA SAUDE::MEDICINA::CLINICA MEDICA::GINECOLOGIA E OBSTETRICIA
Unidade de producción: Instituto de Ginecologia
Editor: Hilaris SRL
Es parte de: Journal of Clinical Case Reports
Volumen: 6
Número: 4
Fecha de publicación: 2016
DOI: 10.4172/2165-7920.1000781
País de edición : Bélgica
Idioma de publicación: eng
Tipo de acceso : Acesso Aberto
ISSN: 2165-7920
Aparece en las colecciones: Ciências da Saúde

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