Preditores de risco para hipoparatireoidismo transitório e permanente após tireoidectomia em uma coorte retrospectiva de hospital universitário

Abstract

Hypocalcemia (hypoCa) is the most common complication of thyroidectomy, affecting up to 30–50% of patients in various series. The main cause is hypoparathyroidism (HypoPT), due to iatrogenic injury to the parathyroid glands. Fortunately, this condition is mostly transient. Objectives: to describe the frequency and clinical predictors associated with transient and permanent HypoPT following thyroidectomy in a university hospital setting. Methods: a retrospective cohort study will be conducted, including all patients who underwent thyroidectomy from 2001 to 2017 at a university hospital. Data will be collected from both electronic and physical medical records. For statistical analysis, three groups will be classified for comparison: patients with benign disease, those with malignancies, and those with Graves’ disease (GD). Patients presenting with hypoCa (corrected serum calcium < 8.5 mg/dL) and/or hyperphosphatemia (hyperP) (serum phosphorus > 4.5 mg/dL) in the postoperative period will be considered to have postsurgical HypoPT. Permanent HypoPT will be defined as: the need for calcitriol or high doses of cholecalciferol to maintain normal calcium levels; persistent hyperphosphatemia; or serum PTH levels below the reference range after 12 months of follow-up.