Prevalência das neoplasias intra-epiteliais cervicais e das lesões induzidas pelo HPV no trato genital inferior em mulheres HIV soro-positivas/AIDS

Abstract

Introduction: the totality of notification in Brazil until 2002 is 237.588 and the number of HIV infected women is the important fact in the HIV epidemic. Objective: to study the prevalence of cervical intraepithelial neoplasia and HPV induced lesions in HIV seropositive/AIDS women, the distribution of these lesions in the lower genital tract and its degrees, correlating them with the CD:+ T Iymphocyte count. Methods: in this study, 130 HIV infected women cases have been analyzed from may 1998 to october 2000, with directed biopsy of the lower genital tract, evaluating lhe distribution of the lesions and its degrees with the CDs + T Iymphocyte count. Results: the prevalence of CIN was 30% and CIN | was the main histologic degree. The histologic degree increased with the reduction of the CD: + T lymphocyte count, except for CIN HI The pure HPV infection was the main finding in the histopathological examination of the vagina, vulva and perianal region with 64,9%, 87,2% and 81,1%, respectively. The main site of infection of the HPV was lhe vulva (34,0%) and of the intraepithelial neoplasias was the uterine cervix (79,5%). Conclusion: there was a high prevalence of CIN among the cervical intracpithelial neoplasias, the CIN | was the main histopathological finding, the impact of the immunosupression influenced the histopathological degrees, excepted CIN II, the main site of the intraepithelial neoplasias was the uterine cervix and of the HPV induced lesions. the vulva, and in both sites the lesions tended to be unicentric.