Gamopatia monoclonal com padrão de glomerulonefrite membranosa em paciente com síndrome nefrótica

Abstract

Monoclonal gammopathy of renal significance (MGRS) is a renal damage caused by a monoclonal immunoglobulin (Ig) in patients who do not meet the diagnostic criteria for hematologic neoplasia. Although this pathology was first described in 2012, it is a cause of important renal disease and should be included in the differential diagnosis of patients with altered renal function associated with proteinuria, with or without the presence of hematuria. Identification of the clone is important for targeted therapy. In the case reported, we have a patient with altered renal function and the presence of an IgG kappa peak in immunofixation of serum and urine proteins, but without criteria for multiple myeloma. After the result of a renal biopsy, the patient underwent treatment with hematology and nephrology.